Since the 16-pin connector was introduced and later revised, melting adapters and PSU/GPU-side connectors on some of Nvidia’s mainstream GeForce gaming GPUs have been rampant. Two of MSI’s recently launched high-wattage PSUs interestingly feature two 12V-2×6 connectors while providing only one standard 8-pin connector (via OC3D). Unless you get a 12V-2×6 to 8-pin adapter, these PSUs are incompatible with most modern-day GPUs from AMD, Intel, and even Nvidia (RTX 30 and prior), apart from a few specific variants.
The industry (or, more specifically, Nvidia) made the shift towards 16-pin connectors to reduce cable clutter and meet the ever-increasing power demand of new GPUs. After the first GPU meltdown wave hit, the 16-pin standard was revised with pin length changes and is now known as 12V-2×6. Reports of melting RTX 50-series GPU connectors and adapters have been making rounds on the internet, even with the improved standard. This time, it is believed Nvidia’s power delivery design might be partially responsible.